.Nature Medicine, Released online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and also epidemiologic analyses revealed that an unique reassortant virus-like descent of the Oropouche infection, which has been flowing in the western Amazon region of Brazil for concerning a many years, is related to the recent human outbreaks between 2022 as well as 2024.